Hale Gamze Ağalar1*, Gökalp İşcan1, Yoshiaki Noma2, Özlem Atlı3, Fatih Demirci1, Neşe Kırımer1
1Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey.
2Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770, Japan.
3Pharmaceutical Toxicology Department, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
*Corresponding author. Email: ecz.halegamze@gmail.com
FULL TEXT: NVEO 2017, Volume 4, Issue 1, Pages 14-17
Abstract
The substrate of this study, 2,5-dimethyl-1,4-benzoquinone (DMBQ), is one of the naturally occurring quinones which is found in insects as a defence metabolite. In the present study, DMBQ was biotransformed by using the micro-fungus Corynespora cassicola. The transformation metabolite was initially screened by TLC and GC-MS, then further characterized by NMR (13C- and 1H-NMR) spectroscopic techniques and was identified as ‘2,5-dimethyl 1,4-benzenediol’. In addition, both the substrate and metabolite was evaluated for the in vitro anticandidal, and antioxidant properties along with XTT-cytotoxicity.
Keywords
Benzoquinone, microbial biotransformation, biological activity, DPPH antioxidant activity
References
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Cite
| Bibtex | @research article { nveo454933, journal = {Natural Volatiles \& Essential Oils}, issn = {}, eissn = {2148-9637}, address = {Badebio Biotechnology Ltd.}, year = {2017}, volume = {4}, pages = {14 – 17}, doi = {}, title = {Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite}, key = {cite}, author = {Ağalar, Hale Gamze and İşcan, Gökalp and Noma, Yoshiaki and Atlı, Özlem and Demirci, Fatih and Kırımer, Neşe} } |
| APA | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . (2017). Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite. Natural Volatiles & Essential Oils, 4 (1), 14-17. Retrieved from http://dergipark.gov.tr/nveo/issue/38920/454933 |
| MLA | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 (2017): 14-17 <http://dergipark.gov.tr/nveo/issue/38920/454933> |
| Chicago | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 (2017): 14-17 |
| RIS | TY – JOUR T1 – Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite AU – Hale Gamze Ağalar , Gökalp İşcan , Yoshiaki Noma , Özlem Atlı , Fatih Demirci , Neşe Kırımer Y1 – 2017 PY – 2017 N1 – DO – T2 – Natural Volatiles & Essential Oils JF – Journal JO – JOR SP – 14 EP – 17 VL – 4 IS – 1 SN – -2148-9637 M3 – UR – Y2 – 2018 ER – |
| EndNote | %0 Natural Volatiles & Essential Oils Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite %A Hale Gamze Ağalar , Gökalp İşcan , Yoshiaki Noma , Özlem Atlı , Fatih Demirci , Neşe Kırımer %T Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite %D 2017 %J Natural Volatiles & Essential Oils %P -2148-9637 %V 4 %N 1 %R %U |
| ISNAD | Ağalar, Hale Gamze , İşcan, Gökalp , Noma, Yoshiaki , Atlı, Özlem , Demirci, Fatih , Kırımer, Neşe . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 / 1 (March 2017): 14-17. |
FULL TEXT: NVEO 2017, Volume 4, Issue 1, Pages 14-17
