Hale Gamze Ağalar1*, Gökalp İşcan1, Yoshiaki Noma2, Özlem Atlı3, Fatih Demirci1, Neşe Kırımer1
1Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey.
2Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770, Japan.
3Pharmaceutical Toxicology Department, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
*Corresponding author. Email: ecz.halegamze@gmail.com
FULL TEXT: NVEO 2017, Volume 4, Issue 1, Pages 14-17
Abstract
The substrate of this study, 2,5-dimethyl-1,4-benzoquinone (DMBQ), is one of the naturally occurring quinones which is found in insects as a defence metabolite. In the present study, DMBQ was biotransformed by using the micro-fungus Corynespora cassicola. The transformation metabolite was initially screened by TLC and GC-MS, then further characterized by NMR (13C- and 1H-NMR) spectroscopic techniques and was identified as ‘2,5-dimethyl 1,4-benzenediol’. In addition, both the substrate and metabolite was evaluated for the in vitro anticandidal, and antioxidant properties along with XTT-cytotoxicity.
Keywords
Benzoquinone, microbial biotransformation, biological activity, DPPH antioxidant activity
References
Mozaina, K., Cantrell, C.L., Mims, A.B., Lax, A.R., Tellez, M.R., Osbrink, W.L.A., 2008. Activity of 1,4-Benzoquinones Against Formosan Subterranean Termites (Coptotermes formosanus), J. Agric. Food Chem.,56, 4021–4026.
Eisner, T., Jones, T.H., Hicks, K., Silberglied, R.E., Meinwald, J., 1977. Quinones and phenols in the defensivesecretions of neotropical opilionids, J. Chem. Ecol., 3(3), 321 329.
Gulaboski, R., Bogeski, I., Mirceski, V., Saul, S., Pasieka, B., Haeri, H.H., Stefova, M., Staneva, J.P., Mitrev, S.,Hoth, M., Kappl, R., 2013. Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers. Scientific Reports, 3, 1865, Doi: 10.1038/srep01865.
Gunbilig, D., Boland, W., 2009. Defensive Agents of Blaps femoralis, a Traditional Mongolian Medicinal Insect, Sci Pharm., 77, 597–604.
Cite
Bibtex | @research article { nveo454933, journal = {Natural Volatiles \& Essential Oils}, issn = {}, eissn = {2148-9637}, address = {Badebio Biotechnology Ltd.}, year = {2017}, volume = {4}, pages = {14 – 17}, doi = {}, title = {Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite}, key = {cite}, author = {Ağalar, Hale Gamze and İşcan, Gökalp and Noma, Yoshiaki and Atlı, Özlem and Demirci, Fatih and Kırımer, Neşe} } |
APA | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . (2017). Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite. Natural Volatiles & Essential Oils, 4 (1), 14-17. Retrieved from http://dergipark.gov.tr/nveo/issue/38920/454933 |
MLA | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 (2017): 14-17 <http://dergipark.gov.tr/nveo/issue/38920/454933> |
Chicago | Ağalar, H , İşcan, G , Noma, Y , Atlı, Ö , Demirci, F , Kırımer, N . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 (2017): 14-17 |
RIS | TY – JOUR T1 – Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite AU – Hale Gamze Ağalar , Gökalp İşcan , Yoshiaki Noma , Özlem Atlı , Fatih Demirci , Neşe Kırımer Y1 – 2017 PY – 2017 N1 – DO – T2 – Natural Volatiles & Essential Oils JF – Journal JO – JOR SP – 14 EP – 17 VL – 4 IS – 1 SN – -2148-9637 M3 – UR – Y2 – 2018 ER – |
EndNote | %0 Natural Volatiles & Essential Oils Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite %A Hale Gamze Ağalar , Gökalp İşcan , Yoshiaki Noma , Özlem Atlı , Fatih Demirci , Neşe Kırımer %T Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite %D 2017 %J Natural Volatiles & Essential Oils %P -2148-9637 %V 4 %N 1 %R %U |
ISNAD | Ağalar, Hale Gamze , İşcan, Gökalp , Noma, Yoshiaki , Atlı, Özlem , Demirci, Fatih , Kırımer, Neşe . “Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite”. Natural Volatiles & Essential Oils 4 / 1 (March 2017): 14-17. |
FULL TEXT: NVEO 2017, Volume 4, Issue 1, Pages 14-17