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Introduction: Arsenicis one of the heavy metals found in drinking water andone of the free radical generators. In comparison, the blue protein C-phycocyanin occupies a unique role among the many bioactive components of Spirulina due to its applications in the food industry and the treatment of some diseases.
Methods: Twenty male rats were used in the experiment, have been divided into four groups, one group of five rats represented the control group. five rats were administered only sodium arsenite 6.3 mg/kg orally, while another five rats administered both C-phycocyanin300 mg/kg and sodium arsenite at the same time; meanwhile, the remaining group of five rats were fed C-phycocyanin only; after that, their hematological and biochemical parameters were examined.
Results: Our results have shown that C-phycocyanin at a dosage of 300 mg/kg could decrease arsenic toxicity by reducing elevated liver enzyme levels AST and ALT and reduction in endogenous antioxidant enzymes SOD, CAT, and MDA. Furthermore, the hematological results of rats fed with C-phycocyanin plus sodium arsenite investigateda staistiaticalimprovement in plateletsand elevated WBC levels,whilethe levels ofhematocrit,hemoglobin and erythrocytesreveals asignificant improvement compared with groups that treated with only sodium arsenite.
Conclusion: It was concluded that arsenic-induced oxidative stress has been attenuated by C-phycocyanin. As a result, C-phycocyanin may be protecting the liver and the entire body from arsenic toxicity.