Low Doses Of Zinc Chloride Decrease The Activation Of Lipid Peroxidation And The Hemodynamic Effects Of Toxic Doses Of Cobalt Small Doses Of Zinc Attenuate The Effects Of Cobalt In Rats

Main Article Content

Oganesyan David Khachaturovich , Brin Vadim Borisovich , Kabisov Oleg Tasoltanovich

Abstract

The authors carried out a study aimed at analyzing the specificity of changes in the parameters of systemic hemodynamics and lipid peroxidation against the background of the introduction of small doses of zinc chloride in conditions of combined and isolated administration of heavy metal salts of cobalt. Experimental cobalt intoxication in Wistar rats was created by daily single administration of cobalt chloride (4 mg/kg) intragastrically using a probe. Zinc chloride (1 mg/kg) was administered in a similar manner, daily for 1 month. The purpose of the experimental studies was to assess the functional state of the cardiovascular system, indicators of which are traditionally the parameters of systemic hemodynamics. Blood pressure was determined invasively by inserting a catheter into the femoral artery; the minute blood volume was assessed by the thermodilution method, for which a thermistor was inserted through the left common carotid artery into the aortic arch. Indicators such as mean arterial pressure, stroke index, cardiac index, specific peripheral vascular resistance were calculated using special formulas.In order to assess the processes of lipid peroxidation, the concentration of hydroperoxides and malondialdehyde in the blood was calculated based on its interaction with thiobarbituric acid. The state of the antioxidant system of rats was assessed by determining the activity of enzymes such as catalase and superoxide dismutase.

Article Details

Section
Articles