Clinical Case Of A Woman's Pregnancy With Acute Intermittent Porphyria And Thrombocytopenia

Abstract

Acute intermittent porphyria is a rare disease of autosomal dominant type of inheritance due to mutations ofthe gene that encodes enzyme porphobilinogen deaminase in heme metabolism. Pregnancy is recognized as one of the factors that can lead to recrudescencesduring this disease. Literature data are limited in description of combination of acute intermittent porphyria and pregnancy to individual cases or a series of cases. We present a case of pregnancy and delivery of a patient with acute intermittent porphyria and thrombocytopenia.
The patient of 29 years old with III pregnancy and an expectedact of delivery was hospitalized in the State Institution "IPOG named after acad. O. M. Lukyanova of the NAMS of Ukraine" at 35 weeks. During her pregnancy she has suffered two moderate attacks. She performed delivery by caesarean section at 38 weeks due to deterioration of the antenatalfetuscondition. During pregnancy, delivery, the postpartum period,permitted medicines were carefully selected. The woman with a child in satisfactory condition were discharged on the 5th day.