A Review on Dietary Poly Phenols: Herbal Neutraceuticals to Combat Nephrotoxicity

Abstract

Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and its third most main cause is due to drug toxicity. Nephrotoxicity defined as any injury in renal caused directly or indirectly by hepatotoxic drug, with acute renal failure, tubulopathies, and glomerulopathies as common clinical presentations. Dietary polyphenols are essential antioxidant agents have shown protective effects in nephrotoxicity. Polyphenols are the largest group of phytonutrients and derived from plant based food including fruits, vegetables, spices, herbs etc. In the present era, there has been a great interest towards the health benefits of dietary polyphenols against oxidative stress related diseases such as diabetes mellitus, cancer, chronic kidney disease etc. Here, the content presents an overview and recent information on dietary polyphenols in context of relevance to the nephrotoxicity.