The Association between Lipocalin 2 and obesity for diabetic Female Type II

Abstract

Diabetes mellitus (DM) is a metabolic condition due to insulin deficiency, insulin resistance, or both, characterized by hyperglycemia. Lipocalin-2 elevated in type 2 diabetes mellitus-related conditions such as heart disease have been identified in previous research. The Lipocalin-2 are correlated with obesity and unregulated diabetes, in spite of  may be useful to consider the consequences of glycemic control and obesity on lipocaline-2.

 There participated 54 patients with diabetes type 2 and 36 non-diabetic, Individuals of two groups to obese and non-obese compare with apparently healthy control. Before the body mass index (kg/m²) has been calculated, weight (kg) and height (m) were measured as a normal weight (18.49-24.99 kg/m²), or obese (>30kg/m²) according to the WHO classification. The ELISA sandwich was used to measure Lipocalin-2. Colorimetric methods were used for calculating FBS and lipid profiles. The LCN2 levels varied greatly for non-obese women in serum (p<0,05) compare with obese patients. Similarly, the disparity for non-obese female patients in LCN2 was substantial relative to female obese serum controls (p<0.05).

The study also has been found  positive correlated with Diabetes duration (r=0.002,p= 0.99), age( r=0.084,p=0.67), VLDL(r=0.354, p=0.07), T.G(r=0.35,p=0.070),total cholesterol (r= -0.037, p=0.85), LDL(r= -0.129, p=0.523), BMI( r=-0.026, p=0.89),and FBG(r =0.261,p= 0.18) while negative corrlated with HDL(r=-0.046, p=0.820),  in the prediabetic obese patients . Iraqi women patients with diabetes have high serum lipocalin-2 levels. The results may be suggested their susceptibility to LCN2-related complications, such as metabolic syndrome, insulin resistance, ischemic heart disease, and diabetic renal disease. However, no significant relation between LCN2 and glycemic control and obesity was found.