Synthesis, characterization and biological activity of mixed ligand complexes of some metal ions containing new 2- Thioxoimidazolidine-4- one derivative and amino acid

Abstract

In the present work, a new derivative of 2- thioxoimidazolidine-4- one (3-{(E)-[(4- hydroxy-3-methoxyphenyl) methylidene] amino} -2- sulfanylideneimidazolidin-4-one) has been synthesized by the reaction of vanillin with thiosemicarbazide then the resulting product reacted  with ethelchloroacetate to produce the ligand. This ligand was characterized using different technique such as elemental analysis (C.H.N.S), (FTIR) and (UV.Vis) and HNMR spectra. This ligand and glycine have been used in the characterization of mixed ligand metal complexes ions, using metal ions [Cu(II), Ni(II), Co(II), Zn(II), and Cd(II)] the synthesized complexes have been also synthesized using available technique such as, Accurate analysis of the elements (C.H.N.S) and atomic absorption spectroscopy, (FT-IR) spectra, conductivity measurement, (UV-Visible) spectra, and (magnetic susceptibility). The biological activity of the prepared complexes were investigated against two kind of bacteria (Escherichia coli as gram negative bacteria and Staphylococcus haemolyticus as gram positive bacteria).