Preparation and Evaluation of Bilayer Tablet For The Treatment Of Hypertension

Abstract

In the present scenario, combination therapy for various types of drugs is used for the disease management by the developed and developing countries. These combinations are also used for the long term treatment like hypertension, other cardiovascular diseases and diabetes. Over 90 to 95% of tablets are taken orally. Bilayer tablet design is the most popular now a days. This may lower the dosing frequency. These tablets have been designed to provide continuous release of the drug substances for complete duration of treatment. Metoprolol succinate and indapamide hemihydrate combination is used in the current study. In bilayer tablet dosage form, the 1^st layer is meant with a prompt releasing and 2^ndlayer is used as the persistent dose. Objective proposedinvestigation is formulating as well as develop bi-layer tablet, which contains metoprolol tartarate as immediate release part and indapamide hemihydrate as a sustained release part. Metoprolol tartarate is a selective β₁-blockeras utilized in managing of high BP, angina pectoris & congestive heart failure. Indapamide hemihydrate belongs to the class of diuretic/antihypertensive. It prevents the absorption of both Na⁺ and K⁺ cations from the kidney.