Appraisal Some Antibiotics Against Uropathogensescherichia Coli:A Cross-Sectional Study

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Jihad N. Abid Albanwawy , Anmar W. Almayyahi , Hayder Kareem Kataa AL-Aidy

Abstract

Aim of Study: A cross-sectional study was conducted to do evaluate the effectiveness of some antibiotics on isolates of Escherichia coli bacteria causing urinary tract infection.


Methodology: This study that aimed to detect effectiveness of some antibiotics on Escherichia coli isolates from Alazizya general hospital in Wasit Province during the period from June 2019 to December 2019. A total of 714 clinical samples that were collected from the patient suffering from urinary tract infection in the hospital. A total of 113 Escherichia coli isolate were detected and choose five types of antibiotics in order to demonstrate their effectiveness and Statistical analysis by Statistical software package SPSS version 16 was used to analyze the data.


Results: These 113 isolates then studied distribution of UTIs by Escherichia coli in female (61%) that was more than male infection (39%),and studied Meropenem,Nitrofurantoin,Ciprofloxacin, Cefotaxime and Amoxicillin/clavulanate disc susceptibility test,it was able to detect Escherichia coli isolates resistant to Cefotaxime (69.06%) and Ciprofloxacin (65.53%), but with amoxicillin/clavulanate was expressed high degrees of resistance about (91.16%). While all isolates were foundhighly sensitive to Meropenem (90.28%) and Nitrofurantoin (86.63%), No significant differences (p < 0.05) were estimated between antibiotic resistances and  gender.                                                                                                                                                                            


Conclusions: High resistanceswere detectedto Amoxicillin/clavulanate, Cefotaxime and Ciprofloxacin which commonly used as empirical treatments for UTIs.  This necessitates continuous surveillance for resistance pattern of uropathogens against antibioticsbecause of this use.


Recommendations



  • Amoxicillin/clavulanate, Cefotaxime and Ciprofloxacin resistant Escherichia coli should be taken in consideration when we are working with hospital cross infection.

  • Further studies on large scale should be performed in order to study resistant coli in the whole country.

  • Antibiotic prescribing policy should be put under observation and guidance inside and outside hospitals.

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