Over Expression Of Foxl 1 In Iraqi Patient With Autism Spectrum Disorder

Abstract

Autism spectrum disorders (ASDs) are a collection of diseases marked by difficulties with reciprocal social interaction and communication and limited and repetitive activities. FOXl1is transcription factors have a distinct DNA-binding forkhead domain and are involved in various processes during ontogenesis, including metabolism, gene expression, and cell proliferation.
Materials and Methods
A case-control study was performed of 60 ASD, and 60 age and sex-matched apparently healthy children control group. Their ages ranged between 3 and 16 years 6.66 ± 3. 051(mean ± SD). Study participants at the transcriptional level of FOXL1 (Forkhead Box L1)were quantitated using the qRT-PCR, ΔΔCT method.
Results: The expression of FOXL1 was significantly higher among autistic patients than that of control participants upregulating FOXL1in autistic patients than control one.
Conclusion: FOXL1 is a candidate gene for ASD.