Formulation And In - Vitro Evaluation Of Ropinirole Nano Suspension

Abstract

Ropinirole (RR) is a non-ergoline dopamine agonist and is the drug of choice in the treatment of patients with Parkinson’s disease and restless leg syndrome. The drug is practically insoluble in water and poses formulation challenges when conventional techniques are attempted in the preparation of a dosage form.Keeping in view of itslow oral bioavailability,the present study was designed and undertakento prepare and characterize anano-Suspension (NS) to enhance its solubility and dissolution characteristics.NS was prepared by homogenization followed by ultrasonication method. Prepared NS was characterized forsolubility, drug content, particle size, surface morphology, sedimentation, stability and in-vitro drug release.The Scanning electron microscopy(SEM) image revealed a change in appearance of the surfaceof the dispersed drug particles. The in vitro drug release studies indicated a significant increasein the dissolution rate as compared with pure drug. The Fourier Transform Infra red spectroscopy (FTIR) has suggested no evidence of interaction of drug and excipient.The present study establishes that the initial crystal structure of RR is reduced when its particle size is reduced and the dissolution properties were improved so that it can be further explored to formulate in the form of a NS with substantial therapeutic gains.