Outcome Of Hypericum Perforatum Tea Consumption On Liver Enzymes And Histology

Abstract

Hypericum perforatum( HP)is an example such remedies, that prescribed to diabetics to control the levels of glucose and lipid. Three groups of 7 albino rats were subjected to HP extract in the form of a prepared tea in a doses of 3cc,6cc,9cc/kg body weight given orally with drinking water, the control group of 4 rats were live in the same environmental conditions.At the end of the study period which was 30 daysanimals were sacrificed, blood aspirated to assay the liver enzymes, named alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), andstatistically compared to the enzymes of the control group. Liver tissue examined microscopically to determine the histological changes associated with the experiments. While the ALT, AST, LDH activities were reduced in the lower dose of HP tea, it started to increase with the moderate and high dose of that preparation. There was a progressive histological changes of liver tissue with the increased dose of HP tea. With the higher dose the was tissue necrosis and karyolysis of the nuclei as well infiltration of lymphocyte and kupffer cells.This lead to conclusion of a progressive liver damage with increased dose, that should be taken in consideration when use this remedy.