CYTOCHEMICAL INDEXES OF PHAGOCYTES AT RATS AT THE COMBINED INFLUENCE OF FACTORS OF THE PRODUCTION ENVIRONMENT

Abstract

The purpose of work was studying of cytochemical indexes of cells of bronchoalveolar washout (BAW) and the red marrow (RM) at the combined impact of the coal and pedigree dust (CPD) and the exercise stress (ES) on the experimental animals. At the combined influence of CPD and ES at the experimental animals, the expressed changes of cytochemical indexes in cells cells, the BAW, and marrow characterizing violations of metabolic compensatory mechanisms are revealed. There are considerable disorders of intracellular metabolism, demonstrating the irreversible disintegration of cells. It is available the phenomena of a lipide degeneration of phagocytes consisting in of excess accumulation of the osmophilic granules in the cytoplasm which are a consequence of a pathological process. The sharp increase in activity of the organellospecific organelle-specific enzyme characterizing a condition of lysosomes revealed by us reflects the destructive catabolic processes in phagocytes. Thus, along with coal and pedigree dust, the exercise stress aggravates the action of a dust factor that is followed enzymatic disorganization of lysosomes and a lipide degeneration of cells. It probably leads to a violation of an intracellular homeostasis and a decrease in viability or death of cells.