Response Of Various Extracts Of Manilkarazapota (L) Seeds Against Periodontitis Triggering Microbiota

Abstract

Oralmicrobiota to predominate periodontitis andadjustment of human pathogen shifted microbiota by plants intended present study to evaluate the response of various extracts of Manilkara zapota (L) seeds against periodontitis triggering pathogens. Present study involvedpreparation of methanol, acetone, petroleum ether, ethanol, and ethyl acetate extracts ofManilkara zapota (L) seeds stems using Soxhlet extractor.The prepared extracts were further evaluated for their potential to inhibit the periodontitis triggering pathogens and subjected to phytochemical screening. The phytochemical screening of different extracts showed presence of alkaloid, flavonoids, glycosides, carbohydrates, and proteins. Among all extracts, the methanol extract of Manilkara zapota seeds showed best antimicrobial profile against strains of Vibrio cholera, Salmonella parthyphi A, andShigellaflexnari. Present study concludes methanolic extract of Manilkara zapota seeds to possess high inhibitory potential against periodontitis triggering pathogens. The high inhibitory potential of methanolic and acetone extract of Manilkara zapota seeds extract could be attributed to the presence of alkaloidal and flavonoidal constituents.