Clinical-Morphological Characteristics Of Tuberculoid Form Of Leprosy After Treatment With Sulfonyl Drugs

Abstract

In this scientific study, morphological changes in the skin in the tuberculoid form of leprosy treated with Sulfonyl drugs were presented. Samples were taken from 22 of the patients treated at the Karakalpak clinic for patients with leprosy after treatment with Sulfonyl, and from 14 patients who did not receive Sulfonyl for comparison. The results showed that in patients treated with Sulfonyl drugs appear tuberculous-shaped foci in the form of atrophic and depigmented centers, the edges of which are thickened in the form of ring-shaped plaques. At the center of the tuberculoid foci, skin tissue structures, including the epidermis, are atrophied and thinned, sweat, sebaceous glands, and hair follicles are atrophied in the dermis, the fibrous connective tissue is thickened, and a rough and hyaline appearance is found. In the periphery of the tuberculoid foci, leprosy-specific granulomatous inflammation is observed, and leprosy nodules appear at various levels along the blood vessels, glands, and hair follicles.