Synthesis, Spectroscopic, Antibacterial, Antifungal, And Toxicity Studies Schiff Base Basing 2-Aminobenzoic Acid Transition Metal Complexes

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Abdul Salam Abdul Kareem Abdul Rahman and Rehab Kadhim Raheem alshemary

Abstract

The new Co(II), Cu(II), Mn(II), Zn(II), and Ni(II) complexes, including H2DAPB by reacting 2- aminobenzoic acid with 4-amino antipyrine and glyoxylic acid. The new complexes were recognized by diverse spectroscopic methods, and the arrangement of the complexes was assured by Mass spectra and (TGA and DTG) thermal analyses. The in vitro antifungal and antibacterial efficiencies of the compounds were screened versus fungi like C. Albicans, A. niger R. stolonifer, and A. flavus, and bacteria such as S. aureus, E. coli, P. aeruginosa, B. subtilis. All the metal complexes offered powerful antifungal and bacterial efficiencies than the ligand. The linking ability of CT-DNA with the complexes was carried out by photophysical (emission titration
/absorption) methods in which an interactive mode of binding was observed. Moreover, outcomes of the DNA-cleavage efficacy propose which the ligand and its metal complexes may cleave CT-DNA at various degrees. Then, the study of interaction for complexes with CT-DNA has been inspected by viscometric and absorption spectral titration determents. Cytotoxicity studies of complexes on (MCF-7) cell line of human breast cancer were screened by EtBr in (MTT) test. Cell viability 50%was given at 25 μg for Cu (II),50 μg for Co(II), 100μg for Mn(II),150μg for Co(II) and 250 μg for Ni(II). The compounds showed significant activity in the biological studies.

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