Anti-Diabetic Potentials Of Vernonioside E Saponin; A Biochemical Study

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Daniel E. Uti , Godwin O. Igile , Wilson A. Omang , Grace U. Umoru , Precious A. Udeozor , Uket N. Obeten , Onyinyechi N. Ogbonna , Udu A. Ibiam , Esther U. Alum , Opotu, Rukayat Ohunene , Mordi Joseph Chukwufumnanya , Rowland I. Oplekwu ,Wilson A, Obio


Aim:Saponinshave been reported to demonstrate glucose lowering potentials in diabetic conditions. This study was aimed at investigating the effect of Vernonioside E (VE), a steroidal saponin extract from Vernoniaamygdalina(VA) in diabetic rats.
Main Methods: A total of 42 Wistarrats used in the study were distributed into seven (7) groups (n=6). Treatment with varying concentrations of Vernonioside E (VE1, VE2, and VE3), controls, normal (NC) and  diabetic (DC) were given placebo treatments, insulin (5 Iμ/kg b.w) (IP) given to the standard control (SC), and
VA crude extract (400mg/kg b.w) per oral to the other group for 21 days.

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