Study Of The Relationship Of The Branched Chain Amino Acids With Lipid Profile In Patients With Type 2 Diabetes Mellitus

Abstract

Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Current study was aimed to observe the total branched chain amino acids (BCAAs),valine, lucien,isoleucine, lipid profile levels and uric acid in type 2 diabetes mellitus patients. The objective of this study was to investigate the association between plasma branched chain amino acids with lipid profile in type 2 diabetes mellitus patients inThi-Qar, Iraq.
Methods: One hundred types 2 diabetes mellitus patients and an additional 75 non-diabetic controls were recruited. Age and body mass indexof the subjects were recorded. Plasmatotal branched chain amino acid, valine, leucineand isoleucine, serum glucose, HbA1c, total cholesterol, triglycerides, high density lipoprotein, very lowdensity lipoprotein and low density lipoprotein, uric acid levels were measured from the collected plasma and serum samples.
Results: Total branched chain amino acid, valine, leucine, isoleucine,the levels of serum glucose, HbA1c, total cholesterol, triglycerides, very low density lipoprotein and low density lipoprotein and uric acid showed significant increase in type 2 diabetes mellitus patients as compared to control group whereas the levels of high density lipoprotein showed a significant decrease in type 2 diabetes mellitus patients in comparison to control subjects ( P <0.05 ). In addition, current study demonstrated the characteristic diabetic dyslipidemia which is characterized by low HDL and high triglyceride. Plasma branched chain amino acid levels remained significantly associated with type 2 diabetes mellitus. Elevated serum BCAAs level are positively associated with dyslipidemia. In addition, glucose homeostasis could play a certain role in BCAAs-related dyslipidemia.