An Overview Of Vitamin D And Ll-37 And Their Correlation With Sepsis

Abstract

Background: Vitamin D is a pro-hormone important for serum calcium and phosphorus homeostasis for proper neuromuscular function and optimal skeletal health. Vitamin D can be obtained from diet or made in the skin after exposure to ultraviolet B radiation from the sun, it is then converted to its major circulating form, 25-hydroxyvitamin D (25(OH)D), by the liver and to its hormonally active form, 1,25-dihydroxyvitamin D (1,25(OH)2D), by the kidney to increase the efficiency of intestinal absorption of calcium as its classic function. Recent studies suggest that Vitamin D exhibits a plethora of effects on the innate and adaptive immune responses, endothelial function and the mucosal barrier. It has been demonstrated that Vitamin D also has a role in the regulation of inflammatory responses against infection. Available evidence suggests that vitamin D deficiency may be a predictor of sepsis or increased mortality rate in critically ill patients.