The Effect Of Helicobacter Pylori Eradication Treatment On Increasing Platelet Count In Patients With Thrombocytopenic Purpura

Abstract

The effect of Helicobacter pylori eradication on platelet count in patients with immunosuppressive thrombocytopenic purpura is contradictory. In this clinical trial, the effect of Helicobacter pylori eradication on platelet count in adult patients with ITP was investigated.
materials and methods : Forty Iranian patients with ITP were studied in two groups. One group was treated with amoxicillin, clarithromycin and omeprazole. The other group received similar placebo values. Platelet count was assessed before treatment and in the first, second and third months after treatment.
Findings : The mean platelet counts before the intervention in the intervention and control groups were 67.85 and 69.4 thousand per cubic millimeter, respectively (p = 0.82). This rate was 107.15 in the intervention group and 71.15 thousand per cubic millimeter in the control group in the third month after treatment (p <0.001). Repeated measures analysis confirmed the effect of positive treatment for Helicobacter pylori eradication on platelet count (p = 0.007).
Conclusion : In this study, it was found that treatment of Helicobacter pylori eradication in patients with immune thrombocytopenic purpura causes a significant increase in platelet count.