Role of the transforming Rost Factor Β in the patogenesis structural remodulation of the Slice Trachy in experimental Tracheobronchitis

Abstract

A study of transforming growth factor β1 was carried out to examine the morphological changes of the tracheal wall in a model of aseptic inflammation. By the 14th day of the experiment TGF-ß1 concentration in plasma was more than 5 times higher than in intact animals. The result of such "overproduction" of TGF-ß1 is rearrangement of tracheal mucosa towards reduction of cells of atrial epithelium, bocalytic cells, appearance of foci of fibrosis spreading to submucosa layer, significant increase in volume proportion of fibrous tissue around cartilage, vessels, glands, as compared to control group. The above suggests that increased TGF-β concentration is an important prognostic criterion for pathological fibrosis.