Biopharmaceutical Study of General Tonic Capsules by in vitro Method

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Maksudova F.H, Mamatkulov Z.U, Baratova M.B, Mirzakamalova D.S

Abstract

One of the main quality indicators of modern drugs are biopharmaceutical indicators, in particular the test “Dissolution” – for solid dosage forms. This article presents the results of research on the development of the "Dissolution" test for Indian ginseng developed at the Tashkent Pharmaceutical Institute. Determination of dissolution rate of drugs from solid dosage forms carried out on the device “Rotating basket”.


According to the results of the experiments, the following conditions for determining the bioavailability of the capsules analyzed by the in vitro method selected. To determine the dissolution profile, two dissolution media used in succession – 0,1 M hydrochloric acid solution (capsules should not dissolve within 60 minutes). And – phosphate buffer solution with pH 7,4 (within 45 minutes, at least 75% of the active substances should secrete), the volume of the medium – 1000 ml, the rotational speed of the basket – 100 rpm, the temperature mode – 37±1℃.

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