Evaluation Of Some Immunological Biomarkers Of Allergic Rhinitis Patients In Wasit Province \ Iraq

Abstract

Background: Allergic rhinitis (AR) is an inflammation of the nasal mucous membranes, and IgE-mediated type 1 hypersensitivity reaction induced by exposure to allergens.
Aim of the study: To measure the serum levels of total immunoglobulin E (tIgE), interleukin-13 (IL-13) and eosinophil cationic protein (ECP), and toestimate whether the determination of C-reactive protein would be used as a marker of inflammation in AR patients, also assessment of corticosteroid resistance and finding the effects of neutrophil serine proteases on AR patients. Materials and Methods: Thisstudy involved 60patients with allergic rhinitis and 30controls,all biomarkerswere measured by use ELISA technique. Results: The results of this study showed a significant increased (P≤0.05) in serum levels of tIgE, IL-13, ECP and hs-CRP, in male and female patients with allergic rhinitis disease compared with the control in both age groups.In AR patients, the serumlevels of HGR-β and NEwere found to be increased significantly.
Conclusion: Depending on our study results, serum levels of tIgE, IL-13, ECP and hs-CRP have a rule in the immune response and can be used as a marker of inflammation in patients with AR in absence of other atopic diseases. Most of patients have resistance or insensitivity to corticosteroid treatment. For the first time, the present study demonstrates the role of serum neutrophil elastase (NE) in the immune response of AR.