Evaluation Of Serum Levels Of Interleukin-10 Among Patients With Type Two Diabetes Mellitus (T2DM)

Abstract

Inflammation has a major role in the etiology and pathophysiology of type 2 diabetes(T2DM). This study aims to assess levels of interleukin-10 in sera from patients with T2DM. The number of participants in this study was 80 individuals.The quantities of interleukin-10 in serum were determined using an enzyme-linked immunosorbent assay method (ELISA). IL-10 concentrations displayed asignificant difference in T2DM patients(Mean ± SD 78.43 ± 4.87), compared with controls (Mean ± SD 94.78 ± 5.61), (P-value 0.00937, T-test 8.924), at P≤0.01. Concentrations of IL-10 in T2DM among males of studied groups showed significant difference comparing to controls(Mean ± SD 76.787 ±3.59 versus Mean ± SD 96.458 ±4.82), (P-value 0.0085, T- test 8.017). Also, there is a significant difference in relation to IL-10 levels of females of diabetic patients in comparison to controls(Mean ± SD 80.062 ±4.05 versus Mean ± SD 93.104 ±4.98), (P-value 0.0267, T-test 7.442). According to the results of the current study we conclude: IL-10 is a major contributor to the onset of type 2 diabetes mellitus and there may be a correlation between low levels of interleukin-10 and type two diabetes.