Correlation Between Shbg And Pregnancy Outcome In Pcos Women Undergoing Icsi Cycle

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Tamara B. Al-Qaisey , Saad S.Al-Dujaily , Amal A. Mohammed


Background: Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of sex steroid hormones. Interest in SHBG has escalated in recent years because of its inverse association with polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, and diabetes type II.
Aim of the study: To determine if there is a correlation between SHBG and pregnancy out come in PCOS women undergoing ICSI cycle .
Patients, Materials and Methods: Sixty infertile Iraqi women with PCOS and non-PCOS criteria from the Higher Institute for Infertility Diagnosis and Assisted Reproductive Technologies clinic were nominated. The women included in the study ranged in age from 20 to 45 years. SHBG levels are measured in serum (on pick-up and transfer days) and follicular fluid. All mature ova from both groups were injected with intracytoplasmic sperm. The outcomes of biochemical pregnancy were recorded, and the relationship between SHBG and pregnancy outcomes was established.
Results: Concentrations of SHBG were found to be significantly higher in infertile women with PCOS (serum and follicular fluid at oocyte retrieval and serum on the day of embryo transfer) than in infertile women without PCOS. In terms of pregnancy outcomes, elevated SHBG levels are an excellent predictor of pregnancy outcomes. More than 17.9 SHBG at pick-up day have a 100 percent prediction of a positive pregnancy outcome.
Conclusions: This study concluded that, levels of SHBG in PCOs was higher than non PCOs female. The elevation of SHBG have an excellent prediction of pregnancy outcome in PCOS women.

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