Synthesis, Characterization And Biological Activity Applications Of New Mefenamic Acid Derivatives

Abstract

In this study, novel mefenamic acid derivatives were prepared as binary and tertiary molecule drug
delivery system binding by hydrazide as a bridge. The compound AY1 was used as a starting material for the
production of tri-molecule pharmaceutical compounds by reacting it firstly with hydrazide to give AY1H,which
reacted with four different carboxylic drugs (Naproxen, Ibuprofen, Captopril, Methyldopa) to produce the new
compounds (AY20-AY23) respectively. All the prepared compounds were characterizedby FT-IR,
1HNMR and
13CNMR. The physical properties of the synthesized compounds were also determined and their solubility in
different solvents. The biological activity as antibacterial effect against different bacteriawas studied and showed
bactericidal effect.