Synthesis of new biological active derivatives and their polymers based on N-substituted Maleimide

Abstract

In this work a new homopolymers [P1-P5] were synthesized from five Maleimide derivatives [M3-M7] using Benzoyl
peroxide BPO as an initiator under nitrogen. Five different drugs (Cefotaxime, Ciprofloxacin, Amoxicillin, Cephalexin, and
Ceftriaxone) carried on Maleimide derivatives in presence of triethylamine. All these monomers and polymers were
investigated by FT-IR, 1H NMR, and GPC, controlled drug release and swelling % was studied at PH 2 and pH 8.0 for
homopolymers [P1-P5]. Intrinsic viscosities were measured and applied the characteristic of solubility for these polymers. The
physical properties, anti-bacterial activity for prepared compounds were investigated, as well as the Thiazolyl blue tetrazolium
bromide (MTT)
reduction assay in vitro in human breast cancer cell line Michigan Cancer Foundation-7(MCF7) were studied for the prepared
polymers.