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This study involved 48 female patients (35 who underwent sleeve gastrectomy and 13 who did not undergo the surgery and constituted the control group) who were obese and had body mass index of 40 kg/m2 and more, and their ages ranged between (20-45) years and from Mosul and Duhok cities. The patients were periodic visitors to the National Center for Obesity Treatment, and their conditions were previously confirmed by specialist doctors after conducting a set of tests, including calculating their body mass index. All the patients who were included in the study met the criteria to be eligible for surgical treatment of obesity. Later, Patients were subjected to sleeve gastrectomy at Al-Zahrawi Private Hospital - Nineveh using laparoscopic surgery by doctors specialized in obesity surgery. The patients were followed up for six months on three intervals; after one month, three months and six months. Laparoscopic sleeve gastrectomy resulted in a significant decrease in the concentration of the ghrelin hormone in the serum of female sleeve gastrectomy patients compared to the control group. The results also showed a significant increase in the concentration of the adiponectin hormone in the serum of females of all groups of gastric sleeve patients during the follow-up period compared with the control group.