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The main problem for type 2 diabetes mellitus is blood glucose instability. This study aimed to determine the effect of binahong leaf decoction in reducing blood sugar levels in patients with type 2 diabetes. Leaf boiled water has made from 100 grams of fresh binahong leaves boiled in 400 ml until the remaining 200 ml. Respondents drank boiled water from binahong leaves two times a day for one week. The tool measured blood sugar levels using a glucometer with the Strip method. Statistical data analysis was carried out using statistical tests, namely Paired T-test with = < 0.05. Binahong leaf decoction reduced blood sugar levels for seven days of consumption. The average decrease in blood glucose is about 33 Mg/dl. Binahong leaves (Anredera cordifolia) can reduce blood glucose levels in patients with type 2 DM because they contain saponins, alkaloids, polyphenols, flavonoids and mono polysaccharides which have insulin-like activity, can inhibit lipolysis, increase glucose uptake by adipose cells so that it can improve insulin resistance Boiled fresh binahong leaves with an adjusted amount based on body weight. It tested on human subjects Optimal dose of binahong leaf ethanolic extract, which has an antidiabetic effect because saponin compounds are also resistant to heating, so they will not be damaged when boiled on binahong leaves binahong leaves do not show signs of toxic abnormalities, so they are considered safe for medical use.