Formulation, Development Of Ibuprofen-Olive Oil Nanoemulsion: 32 Design Approches

Abstract

Ibuprofen, a phenyl propionic acid derivative, has been chosen as model drug in this study. It is postulated that
nanoemulsion may serve as a promising drug delivery strategy to improve the oral absorption. The results
indicated that compared to Ibuprofen suspension, nanoemulsion preparation significantly improved antiinflammatory properties of the drug. Nanoemulsion system in improves the solubility and oral bioavailability of
ibuprofen. A pseudoternary phase diagram was constructed in order to assess and identify a nanoemulsion
region from oil (olive oil), surfactant (glycerol) and different sucrose esters (co-surfactant). Upon identifying such
nanoemulsion region, the colloidal system was then developed as a carrier system for ibuprofen. The selected
nanoemulsion (NE) region was characterised by measuring droplet size, polydispersity index, zeta potential and
morphology. In addition, in vitro study were conducted to evaluate the ability of ibuprofen loaded nanoemulsion
in enhancing the oral bioavailability of the drug upon administration.