The Effect Of Clove (Syzygium Aromaticum) Extract On Rats With Induced Diabetic Nephropathy

Abstract

The present study aims to evaluate the effects of clove extract on rats with induced diabetic nephropathy. Thirtyfive adult rat were divided into 5 groups, 1st group was fed on basal diet kept as negative control group. While
the other rats were injected with streptozotocin (STZ) and glycerol to induce diabetic nephropathy then these
rats were classified into 4 groups as positive control group, while the other three groups were given orally clove
extract at 0.5, 1 and 2 ml/rat respectively. Results: The results revealed that the three tested materials exhibit
significant (P<0.05) decrease in serum glucose level, and an improvement in serum kidney function and lipid
profile, while serum insulin concentrations and HDL-C were significantly (P<0.05) increased. In addition, an
enhancement (P<0.05) of the liver enzymes and antioxidant enzymes (catalase, superoxide dismutase and
glutathione reductase) activities were observed while, serum MDA was significantly decreased as compared to
the positive control group. This study demonstrated that clove extract is suitable for diabetic patient with
nephropathy.