In-Vivo And In-Vitro Modified Release Drug Resistant Into The Alcohol Dose Dumping Formulation: A Review

Abstract

AIDD in modified release dosage formulation has been extensively investigated in both animals and humans. This
review summarizes the findings. These drugs, which can be engineered to release their active ingredients at
specific or delayed timings, are at significant risk of dose dumping. After learning about AIDD, regulators recalled
certain products and issued "black box" warnings on others. Since then, much effort has gone into testing a
formulation's resistance to alcohol. The patient risk is negligible if the preparation and its function are unaffected
by 0–40 percent alcohol in vivo and in vitro.