Effects Of Complex Exercise For 12 Weeks On The Bone Mass Content, Diabetes Risk Factors, Bdnfs, And Inflammation-Related Factors Of Type 2 Diabetic Patients

Abstract

The purpose of this study was to examine the effects of complex exercise for 12 weeks on the bone
mass content, diabetes risk factors(HDL-C, LDL-C, HbA1c, TC, TG), BDNFs, which are brain derived neurotrophic
factors, inflammation-related factors(IL-6, TNF-α) of type 2 diabetic patients. The subjects of this study were 50-
70 years old female type 2 diabetic patients residing in Busan selected through simple random sampling and
assigned to an exercise group of 10 subjects and a control group of 10 subjects. A complex exercise program was
administered to 20 type 2 diabetic patients (10 in an exercise group, 10 in a control group) for 60 minutes per
time, three times per week for 12 weeks and differences in the amounts of changes were analyzed. As for
changes in bone mass content (BMC), whereas the exercise group did not show any significant change, the
control group showed significant decreases and the difference in mean values between the two groups was
significant(p<.01). Among diabetes risk factors, HbA1c was shown to be statistically different between the two
groups after the execution of the complex exercise program(p<.05). HDL-C was shown to be statistically different
between the two groups after the execution of the complex exercise program (p<.01), and changed significantly
in the complex exercise group but not in the control group(p<.01). Changes in BDNF were analyzed and the
results indicated significant intergroup differences (p<.01). The results of analysis of changes in IL-6 also showed
significant intergroup differences (p<.01). Through this study, it could be seen that the 12-week complex exercise
program is effective for the prevention and treatment of diabetes and diabetic complications because the
program improved the factors such as the bone mass content, HDL-C, HbA1c, BDNF, IL-6 of type 2 diabetic
patients.