Isolation, Characterization And In-Silico Studies Of Phytoconstituents Isolated From Chloroform Stem Bark Extract Of Holarrhena Pubescens

Abstract

Holarrhena pubescens (HP) commonly known as Tellicherry bark which has been used by tribals for many therapeutic ailments. Stem bark of HP was collected from local area and extracted using chloroform by soxhlation process and isolated the phytoconstituents from the chloroform extract using column chromatography method by gradient elution technique. Five compounds were isolated from the column out of which 3 compounds were found to be novel from the HP.  Obtained phytoconstituents were checked for Insilco studies using reverse docking process with the help of Schrodinger software and the docking score indicates that the phytoconstituents were found to have very good antidiabetic action.