Develop Suitable Ra Animal Model For The In Vivo Evaluation Of Developed Nano-Emulsion Gel

Abstract

This study details the design, optimization, and assessment of a nanoemulsion (NE)-based gel loaded with Quercetin (QCT) for the efficient treatment of rheumatoid arthritis (RA). QCT- NE was formulated utilizing the Box- Behnken experimental design, which relies on spontaneous emulsification procedures. Two different cell lines, HIG-82 and RAW 264.7, were used to test the cytotoxicity and determine the impact on TNF- production. QCT- NE was shown to suppress LPS-induced TNF- generation while having no harmful effects on synoviocytes. Drug penetration is enhanced in QCT- NE gel, and its rheological behavior is verified to be satisfactory. For RA sufferers as a whole, the QCT-NE gel formulation is a very efficient type of localized treatment.