Methotrexate Use In Thyroid Eye Disease That Does Not Respond To Corticosteroid Therapy

Abstract

A 67-year-old man came to the clinic with moderate to severe bilateral active phase TED by complaining the
decreased vision and the worse condition of double vision. The patient had previously received several cycles of
intravenous corticosteroid therapy from an ophthalmologist; however it did not have a good respond. The patient
was treated and showed significant improvement with methotrexate after several months of use. This case
indicated the highlights on the use of methotrexate as an alternative therapy in the cases of TED that did not
respond to conventional therapy. Based on the case description, the patient was treated with methotrexate after
being evaluated post 16 weeks of administration, it turned out that the patient's condition had a very significant
improvement.