Simulation Of Radiation-Thermal Illness And A Way To Its Treatment

Abstract

Experimental modeling of acute radiation and burn disease was performed both separately and in combination. It was established that external total gamma-irradiation of white rats at the dose of 7.5 Gy causes radiation sickness of a heavy degree with characteristic clinical signs and high lethality of irradiated animals. The modeling of thermal shock by application of a heated to 190 °C metal plate with the holding exposition of 5 and 8 seconds was performed. It was found out, that the burn degree depends on the time of contact with the body surface: its application for 5 seconds caused a burn of III-A degree, 8 - second exposition - IIIB degree, which was proved by the terms of formation, rejection of the eschar and complete healing of thermal lesions. The aggravating effect of ionizing radiation on the course and outcome of combined radiation-thermal pathology was demonstrated. Treatment of studied pathology was carried out with purified turpentine which was injected in doses of 0.2; 0.4; 0.6 and 1.0 ml directly under burned skin area in first hours (1-24) after two-factor (radiation and thermal) exposure to organism. It was experimentally shown that an optimum therapeutic dose of purified turpentine is 0.4 ml under the condition of a single injection of the preparation under the wound surface, which was characterized by 83.3% survival rate and healing of burn wounds on the 36th day of the experiment.