(Comparing The Effects And Adherence To Azithromycin Versus Ceftriaxone In Treatment Of Acute Otitis Media In Pediatric Patients In Karbala City)

Abstract

Objective: the aim of study to evaluate the efficacy ofrelativelyhigh dose of threedays’ oralazithromycin(AZ) regimen in comparisonwith doseof threedays’parenteralceftriaxone(CF) for the treatment of patients with acute otitis media.This study was conducted as a prospective, comparative, open randomized controlledtrial between September 2016 to February 2017,and 204patientswere enrolled from few days to 15 yearsold were diagnosed asacute otitis media(AOM) depending on patient’shistory and performing by otoscopic assessment besides the clinical investigations.Patients were divided into two groups: the first one received azithromycin (10mg/kg) a once oral dose daily for three days, the other group received ceftriaxone(50 mg/kg) daily injection for three days. Then, they were examined according to determined schedule of following up after three days; fourteen days; and three weeks of treatment in order to evaluate the successive therapy or recurrent infection after taken specific regimen of antibiotics.The results showed (79) patientsreceived AZ and (29) of them respond to the treatment and (125) patients received CF, (43) patients respond to treatment, so there were non-significant differences between AZ & CF treatment groups by using Fisher test reflecting the benefit and good complain of oral treatment and injectable one.

Conclusion: could be summarized by findings and approving a non-superiority of CFtreatment responsein compare to AZtreatment response toward AOMamong different age groups selected in the study.