Development And Characterisation (Drug Loading, Drug Release And Expansion Study) Of Carboxymethylcellulose – Sodium Alginate Based Hydrogel As Wound Dressing Application

Abstract

Sodium alginate (SA) and Carboxymethylcellulose (CMC), a cellulose derivative, has been used in wound dressing since it has good biocompatibility, hydrophilic, non-toxic and non-allergenic. This study is to develop and characterize CMC-SA based hydrogel as wound dressing material and also to incorporate Octenidine Dihydrochloride (OCT) as antimicrobial agent into the hydrogel and evaluate its release. The CMC-SA hydrogel was formulated using physical crosslinking method, and PEG was used as plasticizer. Following the formulation, the formulation was visually examined for several characteristics. Expansion study was conducted and Franz cell drug permeation study was done for the drug loaded hydrogel to determine the pattern of OCT release from hydrogel. The resulting hydrogel formulation was clear and, homogenous and showed a good expansion capacity up to 48 hours. 0.5% of OCT is incorporated into the hydrogel and a controlled release pattern was observed in CMC-SA based hydrogel. Based on the expansion study, the CMC-SA-OCT hydrogel is suitable to be used on highly suppurating wound but should be changed every 24 hours. This study has revealed that CMC-SA based hydrogel could be a promising wound dressing material in therapeutic applications and it can be used for highly suppurating wounds due to its characteristics.