Nicholas Sadgrove*, Ben Greatrex and Graham Lloyd Jones
Pharmaceuticals and Nutraceuticals Group, Centre for Bioactive Discovery in Health and Ageing, University of New England Armidale NSW 2351 Australia
*Corresponding author. Email: nsadgrov@une.edu.au
FULL TEXT: NVEO 2015, Volume 2, Issue 2, Pages 30-38
Abstract
Highly chemically variable cineole-rich essential oils were produced from cultivated specimens of the genus Prostanthera (Lamiaceae), currently taxonomically assigned to P. ovalifolia, P. rotundifolia, P. incisa and P. lasianthos. Essential oils were chemically characterised using GC-MS and NMR. The mean inhibitory concentrations against Gram-positive and Gram-negative bacterial species were measured using a microtitre plate broth dilution assay. A selection of these oils were further assayed for antimicrobial activity after being encapsulated at a 1:1 molar ratio using α-cyclodextrin. Cineole-rich essential oils are chemically differentiated by the character of the sesquiterpene oxides cis-dihydroagarofuran and kessane; and the sesquiterpene alcohols globulol, prostantherol and ledol. Within the wider context of common essential oils, this selection of essential oils from Prostanthera demonstrated relatively low inhibitory concentrations (high antimicrobial activity), particularly against Gram-positive organisms. When some of these oils were encapsulated in α-cyclodextrin the antimicrobial activity was generally enhanced by two to four-folds. This enhancement may be a result of encapsulation with reduced evaporation during the assay and emulsion formation which may facilitate delivery to bacterial species. The use of cyclodextrins as a feed and formulation additive should be considered within the context of the antimicrobial activity of cineole-rich essential oils from Prostanthera.
Keywords
prostantherol, encapsulation, α cyclodextrin, antimicrobial, cineole
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Cite
| Bibtex | @ { nveo211767, journal = {Natural Volatiles \& Essential Oils}, issn = {}, eissn = {2148-9637}, address = {Badebio Biotechnology Ltd.}, year = {2015}, volume = {2}, pages = {30 – 38}, doi = {}, title = {α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae)}, key = {cite}, author = {Sadgrove, Nicholas and Greatrex, Ben and Jones, Graham} } |
| APA | Sadgrove, N , Greatrex, B , Jones, G . (2015). α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae). Natural Volatiles & Essential Oils, 2 (2), 30-38. Retrieved from http://dergipark.gov.tr/nveo/issue/19771/211767 |
| MLA | Sadgrove, N , Greatrex, B , Jones, G . “α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae)”. Natural Volatiles & Essential Oils 2 (2015): 30-38 <http://dergipark.gov.tr/nveo/issue/19771/211767> |
| Chicago | Sadgrove, N , Greatrex, B , Jones, G . “α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae)”. Natural Volatiles & Essential Oils 2 (2015): 30-38 |
| RIS | TY – JOUR T1 – α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae) AU – Nicholas Sadgrove , Ben Greatrex , Graham Jones Y1 – 2015 PY – 2015 N1 – DO – T2 – Natural Volatiles & Essential Oils JF – Journal JO – JOR SP – 30 EP – 38 VL – 2 IS – 2 SN – -2148-9637 M3 – UR – Y2 – 2019 ER – |
| EndNote | %0 Natural Volatiles & Essential Oils α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae) %A Nicholas Sadgrove , Ben Greatrex , Graham Jones %T α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae) %D 2015 %J Natural Volatiles & Essential Oils %P -2148-9637 %V 2 %N 2 %R %U |
| ISNAD | Sadgrove, Nicholas , Greatrex, Ben , Jones, Graham . “α-Cyclodextrin encapsulation enhances antimicrobial activity of cineole-rich essential oils from Australian species of Prostanthera (Lamiaceae)”. Natural Volatiles & Essential Oils 2 / 2 (June 2015): 30-38. |
FULL TEXT: NVEO 2015, Volume 2, Issue 2, Pages 30-38
