Gözde Öztürk*, Betül Demirci and Fatih Demirci
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, TURKEY
*Corresponding author. Email: g.ozturkau@gmail.com
FULL TEXT: NVEO 2018, Volume 5, Issue 3, Pages 01-06
Abstract
The main aim of the present study was to investigate the antibacterial effect of the commercial Pharma Grade S. officinalis subsp. lavandulifolia (Lamiaceae) essential oil against the skin pathogen Staphylococcus aureus. The chemical composition of the essential oil was confirmed by GC and GC/MS, simultaneously. Camphor (30.5%), 1,8-cineole (24.8%), α-pinene (6.5%), linalool (4.0%) and linalyl acetate (3.5%) were found as major components. The bioactivity of the essential oil and its main compounds were tested using the in vitro microdilution technique. Minimum inhibitory concentration (MIC) values of α-pinene, essential oil, camphor, linalool and linalyl acetate were in the range of 2.5-10 mg/mL, respectively. The results showed that the tested pathogen was only moderately susceptible against the essential oil and its main compounds when compared with standard antibiotics. In addition, the in vitro antioxidant activity was evaluated using the radical scavenging activity mediated by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The activity range was found more than 30 mg/mL for all tested oil samples, compared with the standard. The results suggested that the oil and its major constituents represent antimicrobial activity supporting its antiseptic use in folk medicinal use.
Keywords
Salvia lavandulifolia Vahl., essential oil, antibacterial activity, antioxidant activity
References
Anonymous, (2006). Clinical and Laboratory Standards Institute (CLSI). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, CLSI M7-A7, Clinical and Laboratory Standards Institute.
Pennsylvania.Anonymous, (2016). Council of Europe. European Pharmacopoeia. 9th ed. Strasbourg: Council of Europe.
Chambers, H.F. & Deleo, F.R. (2009). Waves of resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology, 7(9), 629-641.
Cutillas, A.B., Carrasco, A., Martinez-Gutierrez, R., Tomas, V. & Tudela, J. (2017). Composition and antioxidant, antienzymatic and antimicrobial activities of volatile molecules from Spanish Salvia lavandulifolia (Vahl) essential oils. Molecules, 22, 1382-1397.
Deleo, F.R., Otto M., Kreiswirth, B.N. & Chambers, H.F. (2010). Community-associated methicillin resistant Staphylococcus aureus. Lancet, 375(9725), 1557-1568.
Demirci, F., Bayramiç, P., Göger, G., Demirci, B. & Baser, K.H.C., (2015). Characterization and antimicrobial evaluation of the essential oil of Pinus pinea L. from Turkey. Natural Volatiles & Essential Oils, 2(2), 39-44.
Demirci, F., Güven, K., Demirci, B., Dadandı, M.Y. & Baser, K.H.C., (2008). Antibacterial activity of two Phlomis essential oils against food pathogens. Food Control, 19(12), 1159-1164.
Fanelli, M.D.; Kupperman, B.A., Edelstein, P.H. & Margolis, D.J. (2011). Antibiotics, acne, and Staphylococcus aureus colonization. Archives of Dermatology, 147(8), 917-921.
Joulain, D., König, W. A., (1998). The Atlas of Spectra Data of Sesquiterpene Hydrocarbons. University of Hamburg. E. B. Verlag, Hamburg.
Kintzios, E. S. (2000). Sage: the Genus Salvia, Harwood Academic Publishers, The Netherlands.
Kumarasamy, Y., Byres, M., Cox, P. J., Jaspars, M., Nahar, L. & Sarker, S. D. (2007). Screening seeds of some Scottish plants for free radical scavenging activity. Phytotherapy Research, 21, 615-621.
McLafferty, F. W. & Stauffer, D. B., (1989). The Wiley/NBS Registry of Mass Spectral Data. J. Wiley and Sons.
Nikolic, M., Jovanovic, K.K., Markovic, T., Markovic, D. Gligorijevic, N., Radulovic, S. & Sokovic, M. (2014). Chemical composition, antimicrobial, and cytotoxic properties of five Lamiaceae essential oils. Industrial Crops and Products, 61, 225-232.
Perry, N. S., Bollen, C., Perry, E. K. & Ballard, C. (2003). Salvia for dementia therapy: Review of pharmacological activity and pilot tolerability clinical trial. Pharmacology, Biochemistry, and Behaviour, 75, 651–659.
Pierozan, M.K., Pauletti, G.F., Rota, L., Santos, A.C.A., Lerin, L.A., Di Luccio, M., Mossi, A.J., Atti-Serafini, L., Cansian, R.L., & Vladimir Oliveira, J. (2009). Chemical characterization and antimicrobial activity of essential oils of Salvia L. species. Ciência e Tecnologia de Alimentos, 29(4), 764-770.
Porres-Martínez, M., González-Burgos, E., Carretero, M. E. & Gómez-Serranillos, M. P. (2013). Major selected monoterpenes α-pinene and 1,8-cineole found in Salvia lavandulifolia (Spanish sage) essential oil as regulators of cellular redox balance. Pharmaceutical Biology, 53(6), 921-929.
Tzakou, O., Pitarokili, D., Chinou, I.B. & Harvala, C. (2001). Composition and antimicrobial activity of the essential oil of Salvia ringens. Planta Medica, 67, 81-83.
Usano-Alemany, J., Herraiz-Penalver, D., Cuadrado, J., Diaz, S., Santa-Cruz, M. & Pala-Paul, J. (2012). Seasonal variation of the essential oils of Salvia lavandulifolia: Antibacterial activity. Journal of Essential Oil Bearing Plants, 15(2), 195-203.
Cite
Bibtex | @research article { nveo492329, journal = {Natural Volatiles \& Essential Oils}, issn = {}, eissn = {2148-9637}, address = {Badebio Biotechnology Ltd.}, year = {2018}, volume = {5}, pages = {1 – 6}, doi = {}, title = {Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil}, key = {cite}, author = {Öztürk, Gözde and Demirci, Betül and Demirci, Fatih} } |
APA | Öztürk, G , Demirci, B , Demirci, F . (2018). Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil. Natural Volatiles & Essential Oils, 5 (3), 1-6. Retrieved from http://dergipark.gov.tr/nveo/issue/44347/492329 |
MLA | Öztürk, G , Demirci, B , Demirci, F . “Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil”. Natural Volatiles & Essential Oils 5 (2018): 1-6 <http://dergipark.gov.tr/nveo/issue/44347/492329> |
Chicago | Öztürk, G , Demirci, B , Demirci, F . “Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil”. Natural Volatiles & Essential Oils 5 (2018): 1-6 |
RIS | TY – JOUR T1 – Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil AU – Gözde Öztürk , Betül Demirci , Fatih Demirci Y1 – 2018 PY – 2018 N1 – DO – T2 – Natural Volatiles & Essential Oils JF – Journal JO – JOR SP – 1 EP – 6 VL – 5 IS – 3 SN – -2148-9637 M3 – UR – Y2 – 2019 ER – |
EndNote | %0 Natural Volatiles & Essential Oils Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil %A Gözde Öztürk , Betül Demirci , Fatih Demirci %T Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil %D 2018 %J Natural Volatiles & Essential Oils %P -2148-9637 %V 5 %N 3 %R %U |
ISNAD | Öztürk, Gözde , Demirci, Betül , Demirci, Fatih . “Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil”. Natural Volatiles & Essential Oils 5 / 3 (December 2019): 1-6. |
FULL TEXT: NVEO 2018, Volume 5, Issue 3, Pages 01-06