A Review On Pharmaceutical Hydrotropes

Abstract

The term "hydrotropy" was first coined by Carl A. Neuberg in order to substantially enhance the solubility of weakly soluble solutes in water. So hydrotropy is a solarization process. The term "hydrotrope" refers to the chemicals utilized in the solubilization process known as hydrotropy, where the solubility of a third solute in water is increased by the considerable addition of a second solute. Only 8% of potential new drugs now in development have good solubility and permeability.

There are many new medications and their derivatives available today thanks to advanced research and development. However, despite the fact that these medications may show significant pharmacodynamic activity, Due to poor bioavailability, more than 40% of lipophilic drugs are rejected by pharmaceutical companies.

This review will give an idea about structure of hydrotropes, mechanisms, physical modification, solubility, hydrotropes of green synthesis